EXPERIMENTAL DRUGS / POTENTIAL ANTIBIOTIC THERAPIES AGAINST M. ULCERANS TARGET PROTEIN Clarithromycin 23S rRNA on the 50s ribosomal subunit Rifampicin RNA synthesis through interfering with bacterial RNA-polymerase Streptomycin hinders formyl-methionyl-tRNA to bind with bacterial ribosomal 30S subunit Rifabutin RNA synthesis through interfering with bacterial RNA-polymerase Amikacin "formyl-methionyl-tRNA " Azithromycin Ethambutol Isoniazid (isonicotinic acid hydrazide [INH]) Kanamycin Erythromycin Roxithromycin Linezolid Posizolid Sutezolid "TB47 (pyrazolo[1,5-a]pyridine-3-carboxamides)" QcrB Cytochrome bc1:aa3 P218 The enzyme dihydrofolate reductase (DHFR) Ciprofloxacin DNA gyrase-catalyzed super-coiling of double-stranded DNA Sitafloxacin Bacterial DNA gyrase (topoisomerase II) Moxifloxacin DNA gyrase Ofloxacin DNA gyrase Prulifloxacin DNA gyrase Sparfloxacin DNA gyrase Dapsone Rifalazil Epiroprim Ivermectins Milbemycin oxime and selamectin Imidazopyridine amine telacebec (Q203) respiratory terminal oxidase cytochrome bc1:aa3 "Moxifloxacin, R207910 and linezolid" topoisomerase II (DNA gyrase) and topoisomerase IV Q203 (Telacebec) cytochrome bcc-aa3 terminal oxidase Clofazimine Bedaquiline Rifapentine Pretomanid (PA-824) Mathesia